Try things out 1
Activity of Acetaminophen
Clifford Tse
20529845
Partner – Raminder Dhanoa
TA – Xiao Qi
CHEM 123L - 012
February 6th, 2014
Launch
Acetaminophen, also commonly known as Tylenol, is a great over-the-counter remedies used to relieve pain and reduce fevers. Within this experiment, Acetaminophen will be formed through the effect between p-aminophenol and acetic anhydride. This reaction will certainly incur Acetaminophen as a raw solid being impure, that is purified further more through the use of a recrystallization approach. The purification process requires dissolving a great and recrystallizing as a very solid through the solution. The task is stick to by heat the crude solid to dissolve utilizing a minimal amount of solvent, often referred to as recrystallization solvent. It is then cooled to room-temperature and cooled even further in an ice-bath in order to have the crystals solidify inside the saturated remedy. Both contaminated and filtered crude shades will be acquired through cleaner filtration, a strategy used to distinct the solvent and stable through vacuum pressure. (Stathopulos, 2014) The goal of this research is to identify the burning point in the crude stable, Acetaminophen, in both impure and purified solids. This is certainly accomplished throughout the process of recrystallization. The primitive solids will then be extracted with the use of vacuum purification and further seen in deciding the shedding point. The melting items are determined through applying an apparatus known as MelTemp. The experimental melting level values identified are after that used to always be compared with assumptive listed runs of genuine Acetaminophen.
Fresh Procedure
The experimental treatment used for this experiment was outlined in the CHEM 123L lab manual, Experiment #1. All actions were followed without deviation. Experimental Observation
Mass of p-aminophenol
a few. 00g
Mass of 125mL Erlenmeyer Flask
54. 50g
Mass of Crude Products with 125mL
57. 64g
Mass of Crude Products
3. 14g
Volume of Deionized Water Added
31. 4mL
Mass of Purified Goods with 125mL
57. 01g
Mass of Purified Products
2 . 51g
Melting Point of Elementary Product
160○C - 165○C
Melting Point of Purified Product
160○C - 163○C
Results and Calculations
C6H7NO (s) + C4H6O3 (aq) → C8H9NO2 (s) + C2H4O2 (aq)
Theoretical Deliver
C6H7NO (s)
Mp-aminophenol = 109. 13 g/mol
meters = a few. 00 g
n = m/M
n = zero. 0274 mol
C4H6O3 (aq)
d = 1 . 08 g/mL
V = four mL
Meters = 102. 09 g/mol
m = d by V
meters = four. 32 g
n sama dengan m/M
and = zero. 0423 mol
C6H7NO (s) is the restricting reactant
Mass of Acetaminophen
m sama dengan M x n
m = (151. 16 g/mol) (0. 0274 mol)
m = 5. 14 g
Percent Deliver
= 75. 8 %
Discussion
In this particular experiment, the experimental burning point of both the crude and filtered products have been determined to be one hundred sixty ○C - 165 ○C and 160 ○C -- 163 ○C respectively. When comparing with the theoretical data of Acetaminophen's melting point to always be within the selection of 169 ○C - 168 ○C, the experimental values prove to be fairly close with less than 10% deviation in range principles. When comparing the melting stage of the trial and error value and theoretical benefit, the purified product's burning point can be used as it features complete the recrystallization method sustaining an even more similar attribute to the assumptive sample regarding its houses. When looking at the values, generally there appears to be not any significant dissimilarities between the primitive and filtered product, therefore shows simply no real advantage in exclusively comparing the purified item only because of possible fresh deviations.
Although the experiment seems to have very accurate results when comparing experiment and theoretical values, it could appear as if possible problems may possess incurred along the process. A lot of issues that might have been raised are the instrumental precision of computing proper proportions of acetic anhydride and p-aminophenol. The consequence of having lesser amounts of p-aminophenol...
References: Department of Chemistry 2014 Chemistry Laboratory Manual Fall 2014. University of
Waterloo, Waterloo. (pp. 12-15).
Petrucci, L. H., Sardines, F. G., Madura, L. D., & Bissonnette, C. (2011). General chemistry: Rules and modern day applications. (10 ed., pp. 248-252, 274). Toronto, Ontario: Pearsons Canada Inc.
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